Eleanor Flood is a Seattle cartoonist who created a beloved animated television show. Her husband Joe is doctor for sports team, and she suspects he is having an affair. She is "writing a memoir" but never opens her mail so doesn't know her agent left the business and her contract has been cancelled. She is estranged from her sister Ivy because Ivy's husband is a snobby jerk who insisted his wife sever the relationship not just with Eleanor but with Eleanor’s sweet son Timby.
I didn't like this nearly as much as Where'd You Go Bernadette. The narrative was too fractured and Eleanor, to me, crossed over from eccentric to completely annoying. To be fair, I did not read the book but listened to it. Part of my negative reaction was that the narrator was one of the worst I’ve ever heard, using funny voices in an aural version of mugging for the camera, and actually draining the text of humor. It was painful.